Lithium and Triiodothyronine Augmentation of Antidepressants

Brief Communication Lithium and Triiodothyronine Augmentation of Antidepressants

There are now sufficient data to suggest that lithium is an effective augmentation strategy for patients with major depression who have an inadequate response to all classes of antidepressants (1). A recent metaanalysis supports the efficacy of T3 in treatment-resistant depression (2); these studies involving T3 were in patients taking tricyclic antidepressants, although a recent study supports...

Lithium augmentation of nortriptyline for subjects resistant to multiple antidepressants.

Lithium augmentation, the most studied augmentation strategy for depression, has not been evaluated in patients with a history of non-response to multiple antidepressants. The objective of this study was to assess the efficacy of lithium augmentation for patients with a history of treatment resistant depression who also failed a prospective trial of nortriptyline. We enrolled 92 subjects with t...

Triiodothyronine augmentation for the treatment of depression in substance misusers unresponsive to tricyclic antidepressants.

We report on two substance misusers with depression resistant to tricyclic antidepressant treatment who responded to triiodothyronine augmentation. The management of resistant depression, augmentation strategies with particular reference to triiodothyronine, and the possible mechanism of action of triiodothyronine are discussed.

Ghrelin Serum Concentrations Are Associated with Treatment Response During Lithium Augmentation of Antidepressants

Background Lithium augmentation of antidepressants is an effective strategy in treatment-resistant depression. The proteohormone ghrelin is thought to be involved in the pathophysiology of depression. The purpose of this study was to investigate the association of treatment response with the course of ghrelin levels during lithium augmentation. Method Ghrelin serum concentrations and severity...

Augmentation and Combination Strategies in Antidepressants treatment of Depression